题目：A general method for E-selective olefination of acylsilanes with isocyanides via silver catalysis

作者：Xiu-Xia Liang, Dan-Ni Yang, Xiao-Hui Yan, Peng Wang* and Man-Yi Han* 

单位：Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education; Anhui Provincial Key Laboratory of Synthetic Chemistry and Applications; College of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, People's Republic of China

摘要：Trisubstituted alkenes are valuable intermediates in synthetic organic chemistry. The olefination of acylsilanes is expected to be a useful method for preparing trisubstituted alkenes with a silyl substituent. However, only a few studies exist on this process. Here, a silver-catalyzed olefination reaction between acylsilanes and isocyanides is developed, resulting in E-vinylsilanes with good yields and moderate to excellent stereoselectivities. This method is characterized by its simplicity and generality, applicable to various types of both acylsilanes and isocyanides. Experimental investigations and density functional theory calculations support the notion that the size of the silyl group and the formation of a rigid annular intermediate are critical factors influencing the stereocontrol outcome.

影响因子：4.6

分区情况：一区

链接：https://pubs.rsc.org/en/content/articlelanding/2024/qo/d4qo01528b