题目：Copper-Catalyzed Remote Enantioselective Sulfonylation of Yne-Allylic Esters with Sodium Sulfinates

作者: Meng-Die Li, Zi-Han Wang, Hui Zhu, Xin-Ru Wang, Jia-Run Wang, and Tao-Yan Lin*

单位：Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China

摘要：Impressive progress has been made in the copper-catalyzed asymmetric propargylic substitution (APS) reaction, but its use in remote asymmetric yneallylic substitution remains a challenging topic. Herein, we report the first remote enantioselective coppercatalyzed sulfonylation of yne-allylic esters with sodium sulfinates. The reaction is assumed to occur via a copper-vinylvinylidene species as the key reactive intermediate. The use of readily available starting materials, the mild reaction conditions, and the excellent regio-, enantio- and stereoselectivity, as well as broad substrate scope (>70 examples), show the practicality and attractiveness of this method.

影响因子：16.6

分区情况：一区

链接：https://doi.org/ 10.1002/anie.202313911