题目：Ligand-Controlled Copper-Catalyzed Regiodivergent Sulfonylation of Yne-Vinyl Allylic Esters with Sodium Sulfinates

作者：Hui Zhu (朱辉，2023级研究生), Mingxin Shen, Zi-Han Wang, Genping Huang*, and Tao-Yan Lin* (林桃燕)

单位：^aKey Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Anhui Provincial Key Laboratory of  Synthetic Chemistry and Applications, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China

^bDepartment of Chemistry, School of Science, Tianjin University, Tianjin 300072, P.R. China

摘要：Herein, we report the first ligand-controlled copper catalyzed regiodivergent sulfonylation of yne-vinyl allylic esters with sodium sulfinates. The practicality and attractiveness of this protocol are showcased using readily available starting materials, mild reaction conditions, good regio- and stereoselectivities, and a broad substrate scope. A series of controlled experiments identified a copper divinyl-allenylidene complex as the key intermediate in this reaction. Density functional theory calculations delineate distinct mechanistic pathways for each nucleophilic addition step and elucidate their regioselectivity.

影响因子：11.7

分区情况：一区

年、卷、页：2025, 15, 2415-2423.

链接：https://pubs.acs.org/doi/10.1021/acscatal.4c07043

(文、图:林桃燕 / 审核:韩满意 / 审校:曹静 / 终审:杨振兴)